Synthèse de Trifluoromethoxy- Et - Lyon, France - ICBMS (UMR CNRS 5246)

Description

**Synthèse de trifluoromethoxy
- et difluoromethoxy-molécules. Applications à la chimie médicinale et l'imagerie médicale.**:

- Réf **ABG-123778**
- Sujet de Thèse- 09/05/2024- Contrat doctoral- ICBMS (UMR CNRS Lieu de travail- Lyon - Auvergne-Rhône-Alpes - France- Intitulé du sujet- Synthèse de trifluoromethoxy
- et difluoromethoxy-molécules. Applications à la chimie médicinale et l'imagerie médicale.- Champs scientifiques- Chimie
- Mots clés- Synthèse organique, Fluor, Méthodologie, Imagerie médicale.**Description du sujet**:- We have been involved in this field for several years by developing various reagents and methods to propose new pathways to innovative fluorinated molecules with very specific properties.[3] In particular, we recently described a new efficient reagent to directly introduce CF3O moiety, in a "late-stage" strategy, onto organic substrates.[4] Furthermore, this reagent appeared to be an efficient C(O)F2 generator able to be used in situ as an efficient reagent.[5]- This work will focus on the use of this reagent to propose new access to various molecules bearing a CF3O or a CF2O moieties. This will lead to develop various reactions such as, for instance, C-H functionalizations, couplings, flow chemistry. Furthermore, in order to develop "green synthesis" new activation mode will be also studied, with a particular focus on photochemistry, mechanochemistry and emerging mechanoredox.- These methodological developments will be applied to the functionalization of bioactive compounds in order to propose new compounds with dedicated properties which will be studied.- In addition, the laboratory is also specialized in radiochemistry with fluorine-18 isotope.[5-6] Consequently, some of the previously developed strategies will be used in the design of new diagnostic tools, particularly in the field of neurodegenerative diseases.- Bibliography:
- [1] a) C. Zhang, K. Yan, C. Fu, H. Peng, C. J. Hawker, A. K. Whittaker, _Chem. Rev. _**2022**, _122_, ; b) N. Sheikhi, M. Bahraminejad, M. Saeedi, S. S. Mirfazli, _Eur. J. Med. Chem. _**2023**, _260_, 115758; c) S. Han, Y. Lu, _Eur. J. Med. Chem. _**2023**, _258_, 115586; d) M. Inoue, Y. Sumii, N. Shibata, _ACS Omega _**2020**, _5_, ; e) Y. Ogawa, E. Tokunaga, O. Kobayashi, K. Hirai, N. Shibata, _iScience _**2020**, _23_, [2] a) J. Liu, W. Lin, A. E. Sorochinsky, G. Butler, A. Landa, J. Han, V. A. Soloshonok, _J. Fluorine Chem. _**2022**, _257-258_, 109978; b) A. Loison, F. Toulgoat, T. Billard, G. Hanquet, A. Panossian, F. R. Leroux, _Tetrahedron _**2021**, _99_, 132458; c) A. Tlili, F. Toulgoat, T. Billard, _Angew. Chem. Int. Ed. _**2016**, _55_, ; _Angew. Chem. Int. Ed._ **2016**, _128_, [3] a) K. Grollier, A. De Zordo-Banliat, F. Bourdreux, B. Pegot, G. Dagousset, E. Magnier, T. Billard, _Chem. Eur. J. _**2021**, _27_, ; b) K. Grollier, E. Chefdeville, E. Jeanneau, T. Billard, _Chem. Eur. J. _**2021**, _27_, ; c) F. Brüning, C. R. Pitts, J. Kalim, D. Bornemann, C. Ghiazza, J. de Montmollin, N. Trapp, T. Billard, A. Togni, _Angew. Chem. Int. Ed. _**2019**, _58_, ; d) S. Alazet, L. Zimmer, T. Billard, _Angew. Chem. Int. Ed. _**2013**, _52_, ; _Angew. Chem._ **2013**, _125_, [4] a) O. Marrec, T. Billard, J.P. Vors, S. Pazenok, B. R. Langlois, _Adv. Synth. Catal. _**2010**, _352_, ; b) C. Bonnefoy, A. Panossian, G. Hanquet, F. R. Leroux, F. Toulgoat, T. Billard, _Chem. Eur. J. _**2023**, _29_, e ; c) C. Bonnefoy, E. Chefdeville, A. Panossian, G. Hanquet, F. R. Leroux, F. Toulgoat, T. Billard, _Chem. Eur. J. _**2021**, _27_, [5] C. Bonnefoy, E. Chefdeville, C. Tourvieille, A. Panossian, G. Hanquet, F. Leroux, F. Toulgoat, T. Billard, _Chem. Eur. J. _**2022**, _28_, e [6] J. Colomb, G. Becker, S. Fieux, L. Zimmer, T. Billard, _J. Med. _Chem. _**2014**, _57_, **Prise de fonction**:

- 01/10/2024**Nature du financement**:

- Contrat doctoral**Précisions sur le financement**:
**Présentation établissement et labo d'accueil**:

- ICBMS (UMR CNRS 5246)L'équipe d'accueil est spécialisée en chimie organique du fluor et en imageris médicale.

**Intitulé du doctorat**:

- Doctorat de Chimie Organique**Pays d'obtention du doctorat**:

- France**Etablissement délivrant le doctorat**:

- UNIVERSITE CLAUDE-BERNARD-LYON 1**Ecole doctorale**:

- École Doctorale de chimie (chimie, procédés, environnement)-
- 27/05/2024