Post-doctoral research position in the team "Transcriptional regulation of neural and immune development" at in Strasbourg. - IGBMC

Description

The team Transcriptional regulation of neural and immune development at IGBMC (Institut de Génétique et de Biologie Moléculaire et Cellulaire) in Strasbourg is recruiting a postdoctoral researcher to study macrophage diversity using the model Drosophila melanogaster. The project is funded by an ANR grant and is carried out in close collaboration with the team of Dr. Katrin Kierdorf (University of Freiburg, Germany).

Activités

The recruited researcher will integrate the team Transcriptional regulation of neural and immune development headed by Dr. Angela Giangrande and will be supervised by Dr. Sara Monticelli. The IGBMC is a joint research unit between CNRS, INSERM and University of Strasbourg of around 600 staff scientists. The Institute is housed in Illkirch, adjacent to Strasbourg, and hosts multiple platforms giving access to state-of-the-art technologies including high throughput techniques (Genomeast) and microscopy (ICI). The working language of the laboratory is English.

Modalités de candidature

The post-doctoral contract is for two years extendable and can start in Fall 2024. Potential applicants should submit their applications to For any question, do not hesitate to contact Angela Giangrande ) or Sara Monticelli ).

Associé à :

Missions

The goal of the project is to dissect the intrinsic and extrinsic cues contributing to macrophage diversity across development and adulthood. Beside their role in providing defence against the non self, macrophages are pivotal signalling hubs during development and major actors in diseases (from cancer to neurodegeneration), with context-dependent beneficial or detrimental effects. Macrophage diversity, which likely contributes to their different action in physiological and pathological conditions, remains a major and yet poorly understood feature. High-throughput technologies allowed our laboratory and others to gain first insights on the heterogeneity across/within tissues. However, a connection between the different macrophage states, lineage identity and function is not yet resolved.
The recruited postdoc will use single cell sequencing techniques as well as the extensive genetic toolbox available in Drosophila to define the relative impact of plasticity and adaptation vs. lineage specificity on macrophage function.

Profil

The recruited postdoc should have a strong interest in innate immunity, should preferably have experience in molecular biology, cellular biology and next generation sequencing. Previous experience in Drosophila and confocal microscopy is recommended.