Post Doctoral Fellow - Paris, France - Center of research in myology

Description

Post Doctoral Fellow:

• Employer
• Center of research in myology
• Location
• Paris, IledeFrance (FR)
• Salary
• Salary

will be commensurate with experience following INSERM guidelines

• Closing date 9 Jul 2024
• Discipline

Applied Science, Biomedicine, Health Science, Life Science
Job Type
Postdoctoral
Employment - Hours
Full time
Duration
Fixed term
Qualification
PhD
Sector
Academia- You need to sign in or create an account to a job.

• A twoyear postdoctoral position is available in the laboratory of the Pr. Benveniste and Pr. Allenbach in the Center of Research in Myology (U974 Sorbonne Université-INSERM)._
• The project is fully funded by the ARC foundation and will be done in collaboration with the Immunology-ImmunopathologyImmunotherapy (I3) lab (U959 Sorbonne Université-INSERMAPHP)._
• The Pr. Yves Allenbach will coordinate the projet._

Location

The Center of Research in Myology (CRM) and i3 laboratories are interested in muscle and systemic immune responses in auto-immune conditions.

They developed approaches to identify pathological mechanisms, new biomarkers for diagnosis, and innovative targeted approaches.

Our team, headed by O. Benveniste and Y. Allenbach in CRM, is a
world leader in cardiac and skeletal muscle toxicity of anti-tumor immunotherapy. It is a transversal research team, pioneer in the description and the management of ICI-induced myotoxicity (Allenbach Y et al. Nature Rev Immunol 2019; Salem JE et al. NEJM Our team have established one of the world's largest biobanks of patient tissues with myotoxicity.

I3 is lab
expert in immunology with a unique expertise in identifying antigen-specific T cells through the analysis of T cell receptor repertoire using deep sequencing (Barennes P et al., Nature Biotechnology, 2020).

Project summary and position assignment

ICI-myotoxicity, combining skeletal and or cardiac inflammation, is a rare (0.5%) and unpredictable immune-related adverse events (irAE) but the most severe (up to 60% of fatality).

Thus, it is crucial to identify predictive biomarkers and clarify the pathomechanisms.

For this, our team and i3 lab have obtained jointly a considerable grant from the ARC Foundation for cancer research.

The project aims at:
- identifying specific pathways in cardiac and skeletal muscle tissue for rationale therapeutic targeting and
- identifying predictive T cell clonotypes associated with ICI-myotoxicity

They will contribute to wet and dry lab-based research, including sample management, cell sorting, single cell, single nuclei, AIRRseq, RNASeq, as well as using available workflows developed by the host laboratory (PBMC and tissue transcriptomic analysis, 10X Genomics) and implementing new strategies (Xenium, 10X Genomics).

Profile

• PhD in immunology or solid background in immunology
• Skills in cell sorting, single cell and/or single nuclei, AIIRseq, RNASeq
• Skills in bioinformatics