Research Associate - Paris, France - KYRON

KYRON Paris, France

il y a 5 jours

CDI

Description

We are is using a novel glycan engineering approach to deliver better therapeutics to

those most in need. We engineer drugs by controlling the addition of glycans – essential

sugar molecules found on the surface of drugs – to enhance drug specificity, activity, and

longevity. We have developed a proprietary technology to control the glycans added to

drugs and have a patent pending.

We are a dynamic, international, early-stage startup backed by Entrepreneur First, the

world's leading talent investor, along with European and US investors. We have

established collaborations with KOLs across the globe and is advised by leading professors in

the field and a former Sanofi VP. We have recently won numerous prestigious research

grants including the iLab Concours d'Innovation (BPI France), the Women TechEU (European

Innovation Commission), and Innov'up Leader PIA (BPI France).

Tasks

You will work directly with the Senior Scientist in a dynamic role taking on various projects

and tasks. The role involves a mixture of research and bench work. Your main functions will

include:

• Producing and analyzing recombinant therapeutic proteins from our CHO cell panel

• Optimizing protein expression in our CHO cell lines, coordinating with third parties

where required

• Quality reporting of cell banks

• Identifying collaborators and KOLs from scientific articles, conferences, and

networking, and leading discussions with them

• Establishing and managing collaborations with academic groups

6 rue Jean Calvin – 75005 Paris – France

• Analyzing competitive landscapes, including patent literature

• Contributing to set up and development of in-house analytical studies

• Providing insights and recommendations for strategic decision making

• Supporting in expanding out our laboratory facilities

Requirements

PhD in cell and molecular biology, biochemistry, biological engineering, or other life

science discipline

• Experience in CHO cell line culture and development, which includes:

o Vector design and cloning; Stable and transient transfections; Single cell clone

selection (FACS or serial dilutions); Research Cell Banking (RCB) generation; Cell

line stability assessment studies; Genetic characterization methods (qPCR, whole

genome sequencing)

• Experience in recombinant monoclonal antibody production and purification, which

includes:

o Cell supernatant harvesting and clarifying; Titer measurements (ELISA/Octet);

Antibody purification (affinity and gel filtration chromatography); Protein sample

prep for downstream analysis (buffer exchange, concentrating); in vitro and cell-

based activity assays (antigen binding, ADCC activity, etc.)

• Entrepreneurial mindset:

o As an early-stage start-up, we need someone who can adapt quickly to shifting

priorities, take initiative, and be proactive in contributing to the success of the

team

• Fluency in English

• Excellent command of scientific literature and writing skills

• Ability to multitask and manage multiple projects simultaneously

• Exceptional organizational skills

• Ability to think in a creative manner to solve problems – a strong bias to action

• Able to work in a timely manner to meet tight deadlines

• Quick learner and eager to take on new tasks outside of comfort zone

• Great communication skills and open to both giving and receiving feedback

• A team player who is strongly invested in our mission and is excited to

get involved in all aspects of company building

Benefits

Opportunity to be a member of the founding team of an innovative startup

• Work directly with the Senior Scientist in our dynamic R&D team in the center of

Paris: our labs are based at the IPGG in Paris 5ème, right off Rue Mouffetard

• Competitive research salary

• Employee first mentality. We will do everything we can for employee mental and

physical health. Down time will be respected. Annual leave will be generous. Breaks

are strongly encouraged. Rest is an essential component of productivity

• The opportunity to help bring advanced drugs to the market, improving the lives of

millions of people

We are committed to building a diverse and inclusive workplace. We welcome

applications from people from all walks of life.

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Research Associate - Paris, France - KYRON

Description

Tasks

Requirements

Benefits