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Research Engineer Position in Oncology - Paris, France - Institut Curie
Description
Institut Curie is a major player in the research and fight against cancer. It consists of a Hospital group and a Research Center of more than 1000 employees with a strong international objective of the Research Center is to develop basic research and to use the knowledge produced to improve the diagnosis, prognosis, and therapeutics of cancers as part of the continuum between basic research and innovation serving the patient. The molecular oncology team is located at Curie Paris site but will move to Saint-Cloud Curie site mid-2025 or beginning 2026.The first project aims at characterizing intra-tumoral heterogeneity and its role in resistance to treatments with a focus on interaction between tumor cells and microenvironment. This project, related to both basic and translational cancer research, gathers two teams with complementary expertise on bladder cancer biology and microenvironment. The project focus on muscle invasive bladder cancer (MIBC). We contributed to identify different sub-group of MIBC with potential therapeutic consequences. We notably showed that the basal subgroup presented an activation of the EGFR pathway and should benefit from anti-EGFR therapies. However, modest effects were observed in vivo in preclinical models and no benefit was observed in patients. In the other hand, basal tumors and mix tumors with a basal contingent present the worst prognostic after neo-adjuvant chemotherapy. The second project falls within the theme of the expanding field of molecular epidemiology. The objective will be to identify environmental exposure signatures from tumor sequencing data.
Keywords : Bladder cancer, basal tumors, gene regulatory network, single cell RNA seq, Spatial transcriptomic, PERTURB seq, resistance to treatment, microenvironment, EGFR, chemotherapy, whole exome sequencing, molecular epidemiology, environmental exposure.
Training and Skills required
Training: PhD or Engineer diploma in bioinformatics. Knowledge in cancer biology will be appreciated.
Scientific skills: large scale omics data analysis-bioinformatic tools (R- and Python-), working in INUX environment.
Language skills: ability to write and communicate in English.
Desirable Knowledge, skills, and abilities:
Experience in RNA seq data (Bulk and single cell) and whole exome data analysis is required.
Experience in spatial transcriptomic data analysis will be appreciated.
Experience in gene regulatory network analysis will be appreciated.
Knowledge in cancer biology will be appreciated.
Abilities
Scientific rigor
Excellent analytical and synthetic capabilities
Well organised, ability to work independently together with a high team spirit.
Dynamic personality with passion for innovation and problem-solving
A will to work in a multidisciplinary environment.
Ability to communicate.
All our opportunities are open to people with disabilities
Contract information
Type of contract : Fixed-term contract.
Starting date: as soon as possible
Duration :initially 18 months with a possibility to extend to 3 years.
Working time : full time
Remuneration : according to the current grids of the Institut Curie and to the experience of the candidate
Benefits : Collective catering, reimbursement of transportation fees up to 70%, supplementary health insurance
Location of the position : Institut Curie Paris and then Saint-Cloud (from mid 2025 or early 2006)
Contact
Please send your CV and letter of motivation
Letters of recommendation or references to contact may be asked during the selection process.
Publication date: 06th of May 2024
Deadline for application: end of June 2024
The Institut Curie is an inclusive, equal opportunity employer.
It is also committed to high standards of research integrity.
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