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Gif-sur-Yvette

    Biotransformation and Biodistribution Scientist - Gif-sur-Yvette, France - Servier

    Servier
    Servier Gif-sur-Yvette, France

    il y a 2 semaines

    Default job background
    CDI
    Description

    Nous sommes un groupe pharmaceutique à dimension humaine, international et indépendant, gouverné par une Fondation. Notre modèle, singulier, fait notre fierté mais, surtout, nous permet de servir pleinement notre vocation : « engagés pour le progrès thérapeutique au bénéfice des patients ». Aujourd'hui leader mondial en cardiologie, nous avons choisi de devenir un acteur focalisé et innovant en oncologie d'ici 2030, en ciblant des cancers difficiles à traiter et en y consacrant plus de 70 % de notre budget R&D. Un défi que nous poursuivons en parallèle du développement de notre activité générique pour un accès à des soins de qualité pour tous, et à moindre coût.

    Nous ? passionnés de plus de 50 nationalités, portés par un esprit d'entreprenariat. Chaque jour nous avançons avec et pour les patients, avec et pour nos équipes, portés par l'envie de prendre soin, d'oser, de nous développer, de nous engager pour être utiles à celles et ceux qui en ont besoin.

    Venez vivre et contribuez à faire vivre notre engagement #MovedByYou

    We are seeking a highly motivated individual with experience and knowledge of drug metabolism and related assays to conduct activities related to biotransformation of drugs and drug candidates. This includes working together with and mentoring laboratory scientists on structural elucidation and quantification-based profiling of drug metabolites from small molecules as well as new drug modalities such as antisense oligonucleotides (ASOs) and ADCs using cold or radiolabeled approaches with strong focus on delivery to drug discovery and development projects. Depending on the candidate's previous experience and competencies the position will be at scientist or senior scientist level.

    Responsibilities :

  • Having a solid experience in analytical chemistry and/or in biochemistry with hands-on experience via a PhD/post-doctorate position using High Resolution Mass spectrometry platforms, you will be responsible for the design, conduct and follow up of drug metabolism studies during the discovery and development of new drugs (e.g. small molecules, oligonucleotides) by utilizing either cold or radiolabeled material from in vitro and in vivo studies to support drug design in research phases and MIST considerations in clinical phases.
  • You will be responsible for the assessment of structural elucidation of metabolites from biotransformation studies on small molecule entities as well as other drug modalities (e.g. ASOs, ADCs) by using methods/instruments for the identification and quantification of drug metabolites.
  • You will coordinate timelines for activities and discuss results with the project representative of project team. You will be in charge of the scientific documentation of the studies (study design, reports, databasing etc.).
  • As part of the future development of the team, you will evaluate and implement new tools (in vitro and in silico) and/or technologies to expand our capabilities and enhance efficiency in the field. You will also work in accordance with the current Guidelines.
  • The candidate should demonstrate scientific creativity, teamwork and excellent verbal and written communication skills, and will contribute to the technical and scientific development of the team and to the scientific discussions within the team and the DMPK dept.

    • Profile :

  • The eligible candidate should have a Ph. D. degree (or equivalent experience) in chemistry, biology, pharmacology, biochemistry or in pharmacy or related field, with a minimum of 3-5 years of experience in the areas highlighted in the job description in a pharmaceutical industry environment, contract research organization or public institution.
  • Hands-on experience on sample preparation and structural analysis of small molecules in complex matrix using LC-HRMS/MS. Knowledge of structural elucidation and metabolite prediction software tools is a plus.
  • Experience on new drug modalities such as ASO or ADC as well as expertise in mass spectrometry imaging and/or metabolomic approaches would be a plus.
  • Application of an expert understanding of DMPK, physicochemical property assays and biotransformation to support drug discovery projects as well as development studies.
  • Preparation of study protocols, data summary, study reports, and SOPs.
  • Experience in the design and conduct of animal and human metabolism related studies using cold as well as radiolabeled compounds would be appreciated.
  • Ability to lead related activities and represent biotransformation discipline in matrix project teams.
    Excellent oral and written communication skills including good presentation skills. Demonstrated ability to work independently as well as in a team environment. Prior experience mentoring junior level lab based scientists preferred.

    • Nous sommes engagés pour l'égalité des chances et le développement des talents dans toute leur diversité. Nous accordons autant de valeur à l'expérience qu'à l'envie de s'engager au quotidien pour être utile au progrès thérapeutique au bénéfice des patients. Si vous vous reconnaissez dans cette offre et ces quelques lignes, saisissez cette opportunité de nous rencontrer.

  • Servier

    Biotransformation And Biodistribution Scientist

    il y a 22 heures

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    Venez vivre et contribuez à faire vivre notre engagement #MovedByYou · We are seeking a highly motivated individual with experience and knowledge of drug metabolism and related assays to conduct activities related to biotransformation of drugs and drug candidates. This includes w ...

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    Nous sommes un groupe pharmaceutique à dimension humaine, international et indépendant, gouverné par une Fondation. Notre modèle, singulier, fait notre fierté mais, surtout, nous permet de servir pleinement notre vocation : « engagés pour le progrès thérapeutique au bénéfice des ...