- Under the mentorship of your supervisor, perform De Novo generation of virtual molecules guided by biological data such as activity and ADME properties. Reach Target Product Profile using multi-objective optimization strategies and Reinforcement Learning.
- Set up and run several molecule generative tools (commercial, in-house and public code) using existing data sets. Provide analytics, compare methods, and apply them prospectively on selected drug discovery projects.
- Stay abreast of the latest developments in generative molecular design.
- Currently pursuing or recently completed a degree in Computational Chemistry, Chemoinformatics, Computer Science or a related field.
- Understanding of structural chemistry, molecular biology, and chemical informatics is required.
- Experience with machine learning, with a particular focus on deep learning.
- Strong programming skills in Python and familiar with Jupyter notebooks.
- Experience with workflow design tools (e.g., Knime or Pipeline Pilot) would be desirable.
- Ability to work with large datasets and proficiency in data visualization tools.
- Excellent problem-solving skills and attention to details.
- Strong verbal and written communication skills.
- Opportunity to work on pioneering projects in drug discovery.
- A collaborative environment with teams of experts in various fields.
- Technical and scientific mentoring and professional development opportunities.
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Field Service Multi-collector Mass Spectrometry
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Preventative Maintenance, Installation
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Field Service Multi-collector Mass Spectrometry
il y a 16 heures
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Stagiaire Computational Chemistry - Gif-sur-Yvette, France - Servier
Description
Fondé pour servir la santé, Servier est un groupe pharmaceutique international gouverné par une Fondation, qui aspire à avoir un impact sociétal significatif pour les patients et pour un monde durable. Son modèle unique de gouvernance lui permet de servir pleinement sa vocation avec une vision à long terme : être engagé pour le progrès thérapeutique au bénéfice des patients. Les collaborateurs qui composent le Groupe sont engagés autour de cette vocation commune, source d'inspiration au quotidien. Leader mondial en cardiologie, Servier a pour ambition de devenir un acteur reconnu, focalisé et innovant en oncologie en ciblant des cancers difficiles à traiter. C'est pourquoi le Groupe consacre plus de 50 % de son budget de R&D au développement de thérapies ciblées et innovantes en oncologie. Les neurosciences et les maladies immuno-inflammatoires constituent un futur relais de croissance. Dans ces domaines, Servier se focalise sur un nombre restreint de pathologies spécifiques dans lesquelles une caractérisation précise des patients permet de proposer une réponse thérapeutique ciblée, grâce à la médecine de précision. Pour favoriser l'accès à des soins de qualité pour tous, et à moindre coût, le Groupe propose également une offre de médicaments génériques couvrant la majorité des pathologies, en s'appuyant sur des marques fortes en France, en Europe de l'Est, au Brésil et au Nigeria. Dans tous ces domaines, le Groupe intègre la voix du patient à chaque étape du cycle de vie du médicament. Servier, dont le siège social est basé en France, s'appuie sur une solide implantation géographique dans plus de 150 pays et a réalisé, en 2021, un chiffre d'affaires de 4,7 milliards d'euros.
Job Description
We are seeking a highly motivated and dynamic trainee to join the Computational Chemistry team of Servier R&D in Paris-Saclay. The successful candidate will focus on the assessment and comparison of AI-driven generative tools and their application to drug discovery projects. This position offers the unique opportunity to work with state-of-the-art AI technology in an industrial setting and contribute to groundbreaking projects at the interface of computer science, chemistry, and biology.
Key Responsibilities
Technical Skills and Qualifications
What We Offer
Quel que soit votre domaine d'expertise, votre travail au sein du Groupe Servier contribue à faire avancer le progrès thérapeutique au bénéfice des patients. Vous ferez partie d'équipes reconnues pour leur excellence scientifique et développerez votre plein potentiel dans un environnement professionnel qui vous encourage à vous développer. Des parcours d'intégration sur mesure, des opportunités de mobilité, des formations de qualité, un management responsable, un esprit d'équipe... Tout cela et plus encore dans un lieu de travail axé sur votre bien-être.
Chez Servier, nous sommes engagés dans le progrès thérapeutique au service des besoins des patients. Nous mettons la diversité de nos collaborateurs comme une source de richesse pour l'accomplissement de cette vocation.
