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    Post-doc / Engineer, in vitro and in vivo preclinical tests for electrophysiology recording and stimulation via an innovative medical device - Grenoble, France - Braintech Lab Inserm - UGA U1205

    Braintech Lab Inserm - UGA U1205
    Braintech Lab Inserm - UGA U1205 Grenoble, France

    il y a 2 semaines

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    CDD
    Description

    Missions

    Perform cell characterization around the future medical device: impedance measurement, electrophysiology recording/ stimulation (in vivo/in vitro), signal analysis, immuno-cyto/histo-chemistry, microscopy

    Keep appropriate experimental records and documentation and present the results analysis to the Principal Investigator

    Keep a notebook for the characterization of each medical device

    Participate to animal experimentation and to in vitro cell culture

    Participate to the micro-nanofabrication in clean-room

    Participate to the redaction of publications

    Scientific and technical competences

    Electrophysiology (in vitro cells/tissues and/or in vivo)

    Signal analysis (spike sorting, local field potentials, correlations and fourrier analysis)

    Immune-cyto/histo-chemistry

    Cell culture is a plus (cell line, primary cells)

    Habilitation for animal experimentation (not mandatory but it is a plus)

    Neuroscience, electrochemistry or electronics for neuro-recording

    Soft skills

    Communication skills for a successful interaction with the research team and in particular with the medical/ preclinical staff.

    Ability to learn new techniques, in particular cell culture/ micro-fabrication (clean-room work: optical lithography, material etching and deposition, etc).

    Meticulous work for the reproducibility of biological and technological process

    High motivation for medical research

    Remuneration

    The salary will be adjusted based on qualifications and experience.

    Contact

    Candidate should send a CV and a motivation letter to gaelle.offranc-

    BrainTech Lab is a translational technological research unit dedicated to the development of innovative neurotechnologies for brain diseases. The Lab addresses biomedical needs related to brain tumors, neurodegenerative diseases, or disabilities.

    This post-doc mission will contribute to the validation of the proof-of concept for a new medical device (MD) 'Neuro Snooper' in preclinical models (animal/in vitro), a required step before initiating a clinical trial (Technology Readiness Level from 2/3 to 4). Already existing MDs with electrode wires are either very stiff or with a milli-metric dimension. The ERC work has led to a first generic, miniaturized prototype implant with moderate invasiveness and which design was validated in connection with neurosurgeons. It is in particular suitable for the glioblastoma (GBM) application. In a long-term perspective, it will help to characterize brain signals and hyperexcitability in several brain diseases.



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