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Saint-Cloud

    Postdoctoral Position in Computational Biology - Saint-Cloud, France - Université PSL

    Université PSL
    Université PSL Saint-Cloud, France

    il y a 4 jours

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    À temps plein
    Description

    About us

    Institut Curie Research Center

    Institut Curie is a major player in the research and fight against cancer. It consists of a Hospital group and a Research Center of more than 1000 employees with a strong international representativeness.

    The objective of the Research Center is to develop basic research and to use the knowledge produced to improve the diagnosis, prognosis, and therapeutics of cancers as part of the continuum between basic research and innovation serving the patient.

    Mission

    Laboratory

    The Cavalli Lab is seeking a highly motivated scientist interested in deciphering pediatric brain treatment resistance to join as Postdoctoral Fellow.

    The Cavalli Lab is part of the "Bioinformatics and Computational Systems Biology of Cancer" Unit (U900 INSERM, Mines ParisTech, Institut Curie) at Institut Curie, which consists of ~90 researchers and students. It is a very active and growing interdisciplinary team of bioinformaticians, biologists, physicians, mathematicians, statisticians, physicists, and computer scientists (U900 Unit page).

    The Cavalli Lab, investigates tumor heterogeneity, targeting clinically relevant questions. The goal of our genomic approaches is to explore clinically relevant aspects of brain tumor biology. We pursue this goal using patient samples profiling, investigating temporal and intra-tumoral/spatial heterogeneity as well as tumor/tumor microenvironment interactions in adult gliomas and pediatric brain tumors. Projects in the Cavalli lab are developed within a dynamic and collaborative environment with other researchers and clinicians at Institut Curie and beyond.

    The project

    We seek a highly motivated and talented individual to be part of the ENCOURAGER project, a collaborative effort funded by Fight Kids Cancer. This project focuses on studying the causes of resistance to targeted therapy in pediatric gliomas. The applicant will investigate the longitudinal evolution of gliomas under treatment with the analysis of multi-omic profiling of pediatric glioma PDX models at single-cell resolution. This project is in close collaboration with Dr. Ana Guerreiro Stücklin lab at University Children's Hospital Zurich performing the experiments on the tumor samples and PDX models. The successful candidate should hold a recent PhD, have a track record of creativity in developing analytic strategies. He/she has the ambition to tackle the complexity of tumor biology and intra-tumoral heterogeneity using computational analysis of cutting-edge sequencing datasets.

    Responsibilities

    Drive and develop a scientific project focused on tumor heterogeneity/treatment resistance

    Perform end-to-end data analysis: QC, processing, results, visualization, interpretation...

    Analyze single-cell RNA-seq and single-nucleus ChIP-seq datasets

    Perform high dimensional data analysis and integrative 'omic' data analysis

    Use and develop methods and strategies to investigate treatment resistance mechanism

    Profile

    Training and Skills required

    PhD in bioinformatics, statistics or computer science with knowledge and interest in biology

    Have a track record of creativity in developing analytic strategies

    Strong foundation of knowledge in one or more of the following: genomics, cancer biology, statistics

    Have evidence of scientific accomplishment via peer-reviewed publications

    Excellent computational skills

    Experience working in a Unix environment

    Experience in statistical analysis using R

    Experience with high-throughput sequencing data analysis

    Experience with single-cell RNA-seq analysis is desirable

    Proficiency in English and excellent scientific writing skills

    Understanding of cancer cell biology is an asset as well as experience of collaboration with biologists for solving concrete biological problems

    Abilities

    Must be self-motivated, capable to work in autonomy

    Have a good team spirit

    Ability to communicate with clinicians and biologists

    All our opportunities are open to people with disabilities

    Contract information

    Type of contract: Fixed-term contract

    Starting date: as soon as possible

    Duration: 2 years

    Working time: full time

    Remuneration: according to the current grids

    Benefits: Collective catering

    Location of the position: Saint-Cloud

    Contact

    Please send your CV, letter of motivation and contact information of 3 referees, to Dr. Cavalli

    Deadline for application: April 28th, 2024

    Institut Curie is an inclusive, equal opportunity employer

    and is dedicated to the highest standards of research integrity.



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